Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 9/20 | 0.61 |
| ▸ | AXL | P30530 | 8/20 | 0.61 |
| ▸ | ACVR1 | Q04771 | 7/20 | 0.45 |
| ▸ | BMPR1B | O00238 | 6/20 | 0.44 |
| ▸ | BMPR1A | P36894 | 6/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.44 |
| ▸ | ACVRL1 | P37023 | 6/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18616315 | 0.90 | MERTK (0.60) | MERTKAXLACVR1BMPR1BBMPR1A | |
| SCHEMBL18615387 | 0.90 | MERTK (0.65) | MERTKAXLACVR1BMPR1BBMPR1A | |
| SCHEMBL18611887 | 0.87 | MERTK (0.59) | MERTKAXLACVR1BMPR1BBMPR1A | |
| SCHEMBL18612199 | 0.82 | L3MBTL3 (0.59) | MERTKAXL | |
| SCHEMBL18612197 | 0.78 | MERTK (0.59) | MERTKAXLACVR1BMPR1BBMPR1A | |
| SCHEMBL18581004 | 0.77 | AXL (1.00) | MERTKAXL | |
| SCHEMBL18611892 | 0.77 | MERTK (0.55) | MERTKAXLPIK3CB | |
| SCHEMBL21779411 | 0.75 | AXL (0.60) | MERTKAXLACVR1BMPR1BBMPR1A | |
| SCHEMBL18616305 | 0.74 | AXL (0.59) | MERTKAXLACVR1BMPR1BBMPR1A | |
| SCHEMBL18616317 | 0.74 | ACVR1 (0.56) | MERTKAXLACVR1BMPR1BBMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344613-B1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG A SOCIO HOLDINGS CO LTD (KR) | 2020-03-04 | — | — | EP | disclosed |