Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PPID | Q08752 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CCR8 | P51685 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25635448 | 0.81 | ALDH1A1 (0.47) | PKMNPSR1MEN1KMT2AALDH1A1 | |
| SCHEMBL1848799 | 0.80 | FUCA1 (0.47) | PKMNPSR1SMN1; SMN2PPIDMEN1 | |
| SCHEMBL23948570 | 0.80 | CYP1A2 (0.48) | MEN1KMT2AALDH1A1HSD17B10POLB | |
| SCHEMBL15229052 | 0.79 | TACR1 (0.41) | PKMNPSR1SMN1; SMN2PPIDMEN1 | |
| SCHEMBL28452828 | 0.79 | TACR1 (0.41) | PKMNPSR1SMN1; SMN2PPIDMEN1 | |
| SCHEMBL3541508 | 0.79 | L3MBTL1 (0.53) | PKMNPSR1MEN1KMT2AALDH1A1 | |
| SCHEMBL29143659 | 0.78 | DPP8 (0.49) | PKMSMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL31294333 | 0.78 | DPP8 (0.49) | PKMSMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL30733542 | 0.78 | DPP8 (0.49) | PKMSMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL30733538 | 0.78 | DPP8 (0.49) | PKMSMN1; SMN2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017040606-A1 | ISOXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PULMONARY DISEASES AND DISORDERS | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2017-03-09 | — | — | WO | disclosed |