SCHEMBL18618

SCHEMBL18618

O=C(O)C1(F)CCCCC1

nearest known ligand 0.42

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.42
FFAR3 O14843 1/20 0.35
AKR1C1 Q04828 1/20 0.34
USP2 O75604 1/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
CYP1A2 P05177 1/20 0.34
TSHR P16473 1/20 0.34
BLM P54132 1/20 0.34
CACNA2D1 P54289 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
SLC6A1 P30531 1/20 0.32
HSD11B1 P28845 1/20 0.31
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21230424 1.00 CYP2C19 (0.42) CYP2C19FFAR3AKR1C1USP2ALDH1A1
SCHEMBL30199190 0.97
SCHEMBL2031585 0.97
SCHEMBL30480315 0.91
SCHEMBL988825 0.91
SCHEMBL22867 0.84
Hydrochloric Acid SCHEMBL8937886 0.81
SCHEMBL28822522 0.77 FFAR3 (0.35) FFAR3AKR1C1
SCHEMBL31276628 0.77 FFAR3 (0.35) FFAR3AKR1C1
SCHEMBL10872502 0.77 CYP2C19 (0.32) CYP2C19USP2ALDH1A1LMNACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2608669-A1 NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS Merck Sharp & Dohme Corp. (US) 2013-07-03 EP claimed
WO-2012027236-A1 NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS SCHERING CORPORATION (US) 2012-03-01 WO claimed
CN-101098871-A Novel spirotropane compounds and methods for the modulation of chemokine receptor activity VIROCHEM PHARMA INC (CA) 2008-01-02 CN claimed
CN-101001860-A Heterocyclic antiviral compounds ROCHE PALO ALTO LLC (CH) 2007-07-18 CN claimed
EP-1521828-A2 PRODUCTION OF POLYKETIDES Biotica Technology Limited (GB) 2005-04-13 EP claimed
WO-2004007709-A2 PRODUCTION OF POLYKETIDES BIOTICA TECHNOLOGY LIMITED (GB) 2004-01-22 WO claimed
CN-112189010-B Triazole N-linked carbamoyl cyclohexyl acid as LPA antagonists 百时美施贵宝公司 2026-05-15 CN disclosed
WO-2026090300-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC. (US) 2026-04-30 WO disclosed
EP-4724437-A1 METHODS OF TREATING INFLAMMATORY DISEASES Interline Therapeutics, Inc. (US) 2026-04-15 EP disclosed
US-20260091026-A1 METHODS OF TREATING INFLAMMATORY DISEASES INTERLINE THERAPEUTICS INC (US) 2026-04-02 US disclosed
US-20250145595-A1 ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 UNITED STATES GOVERNMENT 2025-05-08 US disclosed
WO-2025072539-A1 AMINO ACID COMPOUNDS WITH NITROGEN LINKERS AND USES THEREOF PLIANT THERAPEUTICS, INC. (US) 2025-04-03 WO disclosed
US-20250057815-A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS BRISTOL MYERS SQUIBB CO (US) 2025-02-20 US disclosed
CN-101001860-A Heterocyclic antiviral compounds ROCHE PALO ALTO LLC (CH) 2007-07-18 CN disclosed
US-20060078980-A1 Production of polyketides and other natural products GREGORY MATTHEW A 2006-04-13 US disclosed
US-20050272132-A1 Production of polyketides and other natural products BIOTICA TECHNOLOGY LIMITED (GB) 2005-12-08 US disclosed
CN-1642913-A Piperidine or 8-aza-bicyclo[3.2.1]oct-3-yl derivatives useful as modulators of chemokine receptor activity (especially CCR5) ASTRAZENECA AB (SE) 2005-07-20 CN disclosed
EP-1521828-A2 PRODUCTION OF POLYKETIDES Biotica Technology Limited (GB) 2005-04-13 EP disclosed
WO-2004007709-A2 PRODUCTION OF POLYKETIDES BIOTICA TECHNOLOGY LIMITED (GB) 2004-01-22 WO disclosed
US-4555370-A CYANTATION OF ACYL. FLUORIDE BAYER AKTIENGESELLSCHAFT (DE) 1985-11-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260091026-A1 METHODS OF TREATING INFLAMMATORY DISEASES NR3C1, NR3C2, CCR1 CYP2C19 864/4885FFAR3 258/4885AKR1C1 104/4885
US-20250145595-A1 ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 CHRM4, CHRM3, CHRM5 CYP2C19 1671/4885FFAR3 247/4885AKR1C1 861/4885
US-20250057815-A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS LPAR3, LPAR1, LPAR2 CYP2C19 1493/4885FFAR3 8/4885AKR1C1 1377/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.