Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 3/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | POLQ | O75417 | 3/20 | 0.33 |
| ▸ | DHODH | Q02127 | 2/20 | 0.32 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | VNN1 | O95497 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185613 | 0.93 | SMO (0.33) | LIPEFAAHTRPV1PDE10ACNR2 | |
| SCHEMBL185331 | 0.92 | DHODH (0.35) | LIPEFAAHTRPV1DHODHCNR2 | |
| SCHEMBL186651 | 0.91 | CNR2 (0.39) | LIPETRPV1CNR2 | |
| SCHEMBL185280 | 0.91 | PIK3CA (0.36) | LIPEFAAHTRPV1DHODHCNR2 | |
| SCHEMBL185910 | 0.91 | FAAH (0.32) | LIPEFAAHTRPV1CNR2EGFR | |
| SCHEMBL2806524 | 0.90 | BRAF (0.38) | LIPEPOLQDHODHBRAFPDE10A | |
| SCHEMBL185223 | 0.89 | FAAH (0.35) | LIPEFAAHTRPV1MAPK14 | |
| SCHEMBL14856612 | 0.88 | MAPK10 (0.33) | LIPEFAAHTRPV1NTRK1BRAF | |
| SCHEMBL185136 | 0.85 | OPRL1 (0.32) | FAAHTRPV1CNR2 | |
| SCHEMBL2804955 | 0.83 | PIK3CA (0.36) | DHODHCNR2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |