Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.32 |
| ▸ | LIPE | Q05469 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185613 | 0.92 | SMO (0.33) | FAAHTRPV1LIPECNR2 | |
| SCHEMBL186205 | 0.91 | LIPE (0.36) | FAAHTRPV1LIPEEGFRKDR | |
| SCHEMBL185331 | 0.91 | DHODH (0.35) | FAAHTRPV1LIPEKDRCNR2 | |
| SCHEMBL186651 | 0.91 | CNR2 (0.39) | TRPV1LIPECNR2 | |
| SCHEMBL185280 | 0.91 | PIK3CA (0.36) | FAAHTRPV1LIPEEGFRCNR2 | |
| SCHEMBL2809360 | 0.90 | BDKRB1 (0.33) | EGFRKDRCNR2FPR2 | |
| SCHEMBL185223 | 0.89 | FAAH (0.35) | FAAHTRPV1LIPE | |
| SCHEMBL185885 | 0.89 | FAAH (0.35) | FAAHTRPV1EGFRFPR2 | |
| SCHEMBL14856612 | 0.87 | MAPK10 (0.33) | FAAHTRPV1LIPEKDR | |
| SCHEMBL185136 | 0.85 | OPRL1 (0.32) | FAAHTRPV1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |