Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | CFTR | P13569 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25632367 | 0.95 | MEN1 (0.36) | KDM4ESMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL24656125 | 0.80 | MEN1 (0.35) | SMN1; SMN2MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL22166764 | 0.77 | KDM4E (0.41) | KDM4ESMN1; SMN2MEN1KMT2AUSP2 | |
| SCHEMBL14752201 | 0.77 | KDM4E (0.37) | KDM4ESMN1; SMN2MEN1KMT2AUSP2 | |
| SCHEMBL23546705 | 0.72 | KDM4E (0.38) | KDM4ESMN1; SMN2USP2ALDH1A1CYP1A2 | |
| SCHEMBL13328166 | 0.71 | TP53 (0.39) | KDM4ESMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL23890951 | 0.71 | POLB (0.43) | KDM4ESMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL12996126 | 0.71 | POLB (0.39) | KDM4ESMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL24415145 | 0.70 | POLB (0.42) | SMN1; SMN2MEN1KMT2AALDH1A1ALOX15 | |
| SCHEMBL22330359 | 0.68 | MEN1 (0.42) | SMN1; SMN2MEN1KMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9593109-B2 | Bicyclic agonists of GPR131 and uses thereof | CYMABAY THERAPEUTICS, INC. (US) | 2017-03-14 | — | — | US | disclosed |