Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12996126 | 0.98 | POLB (0.39) | POLBMAPK1MEN1KMT2AHDAC6 | |
| SCHEMBL14752201 | 0.93 | KDM4E (0.37) | POLBMAPK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22330359 | 0.86 | MEN1 (0.42) | POLBMAPK1MEN1KMT2AHDAC6 | |
| SCHEMBL24656125 | 0.75 | MEN1 (0.35) | POLBMAPK1MEN1KMT2AHDAC6 | |
| SCHEMBL18622281 | 0.70 | KDM4E (0.34) | POLBMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL23546705 | 0.70 | KDM4E (0.38) | POLBSMN1; SMN2ALDH1A1PI4KAPI4K2B | |
| SCHEMBL14754853 | 0.70 | KDM4E (0.34) | POLBSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL14030375 | 0.67 | POLB (0.58) | POLBMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL14030255 | 0.67 | POLB (0.58) | POLBMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL13377191 | 0.66 | SMN1; SMN2 (0.44) | POLBMAPK1MEN1KMT2AHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220144854-A1 | MACROCYCLIC COMPOUNDS | ZENO MANAGEMENT, INC. | 2022-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220144854-A1 | MACROCYCLIC COMPOUNDS | MCL1, BCL9, CYC1 | POLB 3674/4885MAPK1 1102/4885MEN1 372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.