Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.33 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12996126 | 0.94 | POLB (0.39) | KDM4EALDH1A1SMN1; SMN2POLBMEN1 | |
| SCHEMBL24415145 | 0.93 | POLB (0.42) | ALDH1A1HSD17B10SMN1; SMN2ALOX15POLB | |
| SCHEMBL22330359 | 0.82 | MEN1 (0.42) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL18622281 | 0.77 | KDM4E (0.34) | KDM4EALDH1A1HSD17B10SMN1; SMN2TDP1 | |
| SCHEMBL14754853 | 0.77 | KDM4E (0.34) | KDM4EALDH1A1HSD17B10SMN1; SMN2TDP1 | |
| SCHEMBL23546705 | 0.77 | KDM4E (0.38) | KDM4EALDH1A1HSD17B10SMN1; SMN2TDP1 | |
| SCHEMBL24656125 | 0.70 | MEN1 (0.35) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL14030258 | 0.64 | POLB (0.47) | KDM4EALDH1A1CYP1A2POLBMEN1 | |
| SCHEMBL13377167 | 0.63 | SMN1; SMN2 (0.41) | KDM4EALDH1A1HSD17B10SMN1; SMN2TDP1 | |
| SCHEMBL13377027 | 0.63 | SMN1; SMN2 (0.44) | KDM4EALDH1A1HSD17B10SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192720-A1 | MACROCYCLIC COMPOUNDS | ZENO MANAGEMENT, INC. | 2023-06-22 | — | — | US | disclosed |
| US-20230192720-A1 | MACROCYCLIC COMPOUNDS | ZENO MANAGEMENT, INC. | 2023-06-22 | — | — | US | disclosed |
| US-20220144854-A1 | MACROCYCLIC COMPOUNDS | ZENO MANAGEMENT, INC. | 2022-05-12 | — | — | US | disclosed |
| US-9593109-B2 | Bicyclic agonists of GPR131 and uses thereof | CYMABAY THERAPEUTICS, INC. (US) | 2017-03-14 | — | — | US | disclosed |
| US-9593109-B2 | Bicyclic agonists of GPR131 and uses thereof | CYMABAY THERAPEUTICS, INC. (US) | 2017-03-14 | — | — | US | disclosed |
| US-20130059845-A1 | BICYCLIC AGONISTS OF GPR131 AND USES THEREOF | METABOLEX, INC. | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192720-A1 | MACROCYCLIC COMPOUNDS | MCL1, BCL2A1, BCL2L1 | KDM4E 2397/4885ALDH1A1 1086/4885HSD17B10 3206/4885 |
| US-20220144854-A1 | MACROCYCLIC COMPOUNDS | MCL1, BCL9, CYC1 | KDM4E 610/4885ALDH1A1 276/4885HSD17B10 3262/4885 |
| US-20130059845-A1 | BICYCLIC AGONISTS OF GPR131 AND USES THEREOF | GPR119, GPR88, GPR3 | KDM4E 4392/4885ALDH1A1 2048/4885HSD17B10 1243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.