Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 3/20 | 0.54 |
| ▸ | CFTR | P13569 | 1/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | DNASE1L3 | Q13609 | 1/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 5/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23762806 | 0.89 | ABCB1 (0.54) | ABCB1USP2CFTRPAX8ATM | |
| SCHEMBL19269178 | 0.86 | ABCB1 (0.59) | ABCB1USP2CFTRPAX8ATM | |
| SCHEMBL23762510 | 0.85 | ABCB1 (0.54) | ABCB1USP2CFTRPAX8ATM | |
| SCHEMBL17695458 | 0.84 | ABCB1 (0.61) | ABCB1USP2CFTRPAX8ATM | |
| SCHEMBL10082964 | 0.83 | ABCB1 (0.59) | ABCB1USP2CFTRPAX8ATM | |
| SCHEMBL23378600 | 0.82 | ABCB1 (0.64) | ABCB1USP2CFTRPAX8ATM | |
| SCHEMBL20470443 | 0.82 | ABCB1 (0.61) | ABCB1USP2CFTRPAX8ATM | |
| SCHEMBL23378592 | 0.82 | ABCB1 (0.58) | ABCB1USP2CFTRPAX8ATM | |
| SCHEMBL23182127 | 0.81 | ABCB1 (0.58) | ABCB1USP2CFTRPAX8ATM | |
| SCHEMBL14176752 | 0.81 | ABCB1 (0.62) | ABCB1USP2CFTRPAX8ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873866-B2 | Mutant dehalogenase proteins | PROMEGA CORPORATION (US) | 2018-01-23 | — | — | US | disclosed |
| US-20170137793-A1 | POLYNUCLEOTIDES ENCODING MUTANT HYDROLASE PROTEINS WITH ENHANCED KINETICS AND FUNCTIONAL EXPRESSION | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2017-05-18 | — | — | US | disclosed |
| US-9593316-B2 | Polynucleotides encoding mutant hydrolase proteins with enhanced kinetics and functional expression | PROMEGA CORPORATION (US) | 2017-03-14 | — | — | US | disclosed |