Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18626504 | 0.84 | LMNA (0.46) | MAP4K4 | |
| SCHEMBL19008143 | 0.83 | ALDH1A1 (0.49) | MAP4K4KCNH2SMN1; SMN2MAPK1 | |
| SCHEMBL25540177 | 0.83 | USP2 (0.43) | KCNH2SMN1; SMN2 | |
| SCHEMBL15587397 | 0.82 | MAP4K4 (0.50) | MAP4K4KCNH2CDK4CDK6SMN1; SMN2 | |
| SCHEMBL18137749 | 0.82 | MAP4K4 (0.50) | MAP4K4KCNH2CDK4CDK6SMN1; SMN2 | |
| SCHEMBL21092818 | 0.79 | ALDH1A1 (0.54) | SMN1; SMN2KDM2B | |
| SCHEMBL17896304 | 0.78 | KCNH2 (0.50) | MAP4K4KCNH2CDK4CDK6SMN1; SMN2 | |
| SCHEMBL17896799 | 0.76 | ALDH1A1 (0.60) | SMN1; SMN2 | |
| SCHEMBL18626468 | 0.76 | HRH3 (0.51) | MAP4K4SMN1; SMN2 | |
| SCHEMBL13020890 | 0.75 | MAPK1 (0.55) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9592235-B2 | Aminoquinazoline and pyridopyrimidine derivatives | GENENTECH, INC. (US) | 2017-03-14 | — | — | US | disclosed |