Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.34 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186511 | 0.93 | OPRL1 (0.39) | BTKOPRL1PTK2CNR2LRRK2 | |
| SCHEMBL186561 | 0.93 | OPRL1 (0.36) | BTKOPRL1PTK2CNR2LRRK2 | |
| SCHEMBL185483 | 0.93 | OPRL1 (0.38) | BTKOPRL1PTK2CNR2FAAH | |
| SCHEMBL186119 | 0.92 | PTK2 (0.37) | BTKPTK2CNR2LRRK2TRPV1 | |
| SCHEMBL185517 | 0.91 | OPRL1 (0.37) | BTKOPRL1PTK2CNR2FAAH | |
| SCHEMBL199266 | 0.91 | OPRL1 (0.36) | BTKOPRL1PTK2CNR2FAAH | |
| SCHEMBL185009 | 0.90 | BTK (0.37) | BTKPTK2CNR2FAAHTRPV1 | |
| SCHEMBL185881 | 0.90 | OPRL1 (0.37) | BTKOPRL1CNR2FAAHTRPV1 | |
| SCHEMBL14856567 | 0.90 | OPRL1 (0.35) | OPRL1CNR2LRRK2FAAHMAPK3 | |
| SCHEMBL2808552 | 0.89 | PTK2 (0.41) | BTKOPRL1PTK2CNR2VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |