Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 20/20 | 0.56 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185247 | 0.91 | CCR4 (0.59) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL356729 | 0.87 | CCR4 (0.73) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL186432 | 0.85 | CCR4 (0.56) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL185924 | 0.84 | CCR4 (0.51) | CCR4 | |
| SCHEMBL30456 | 0.83 | CCR4 (0.60) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL185668 | 0.81 | CCR4 (0.53) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL186085 | 0.79 | CCR4 (0.75) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL357460 | 0.78 | CCR4 (0.79) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL18560 | 0.78 | GRIN1 (0.47) | CCR4 | |
| SCHEMBL186311 | 0.77 | GRIN1 (0.42) | CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401270-A1 | PYRAZOLE DERIVATIVES USED AS CCR4 RECEPTOR ANTAGONISTS | Glaxo Group Limited (GB) | 2012-01-04 | — | — | EP | disclosed |