Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 10/20 | 0.41 |
| ▸ | UBA3 | Q8TBC4 | 8/20 | 0.41 |
| ▸ | UBA6 | A0AVT1 | 3/20 | 0.41 |
| ▸ | SAE1 | Q9UBE0 | 3/20 | 0.41 |
| ▸ | ATG7 | O95352 | 1/20 | 0.41 |
| ▸ | UBA7 | P41226 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | GRK5 | P34947 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.36 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.33 |
| ▸ | PER2 | O15055 | 1/20 | 0.32 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.32 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23080267 | 0.87 | NAE1 (0.39) | NAE1UBA3UBA6SAE1ATG7 | |
| SCHEMBL18630398 | 0.83 | NAE1 (0.59) | NAE1UBA3UBA6SAE1ATG7 | |
| SCHEMBL23080284 | 0.83 | NAE1 (0.59) | NAE1UBA3UBA6SAE1ATG7 | |
| SCHEMBL23080243 | 0.78 | NAE1 (0.58) | NAE1UBA3UBA6SAE1ATG7 | |
| SCHEMBL23080225 | 0.78 | NAE1 (0.58) | NAE1UBA3UBA6SAE1ATG7 | |
| SCHEMBL23080237 | 0.77 | NAE1 (0.57) | NAE1UBA3UBA6SAE1ATG7 | |
| SCHEMBL20007970 | 0.76 | DNPH1 (0.38) | NAE1UBA3 | |
| SCHEMBL1796354 | 0.75 | UBA6 (0.69) | NAE1UBA3UBA6SAE1ATG7 | |
| SCHEMBL17900861 | 0.75 | UBA6 (0.69) | NAE1UBA3UBA6SAE1ATG7 | |
| SCHEMBL1796353 | 0.75 | UBA6 (0.69) | NAE1UBA3UBA6SAE1ATG7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170073367-A9 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | MILLENIUM PHARMACEUTICALS, INC. | 2017-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170073367-A9 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | TYMP, TYMS, PPA1 | NAE1 257/4885UBA3 235/4885UBA6 2037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.