Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.38 |
| ▸ | HAO2 | Q9NYQ3 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | LTK | P29376 | 1/20 | 0.34 |
| ▸ | GRK5 | P34947 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | MST1R | Q04912 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18632534 | 0.86 | SCN5A (0.54) | SCN5APDPK1NOTUMMKNK1MKNK2 | |
| SCHEMBL18632538 | 0.86 | SCN5A (0.57) | SCN5APDPK1NOTUMCHEK1GRM2 | |
| SCHEMBL253974 | 0.83 | SCN5A (0.57) | SCN5APDPK1NOTUMCHEK1MKNK1 | |
| SCHEMBL18632525 | 0.81 | SCN5A (0.51) | SCN5APDPK1NOTUMMKNK1MKNK2 | |
| SCHEMBL18632514 | 0.80 | SCN5A (0.50) | SCN5APDPK1NOTUMCHEK1GRM2 | |
| SCHEMBL18632535 | 0.79 | SCN5A (0.62) | SCN5APDPK1NOTUMCHEK1GRM2 | |
| SCHEMBL18632530 | 0.79 | SCN5A (0.62) | SCN5APDPK1NOTUMCHEK1GRM2 | |
| SCHEMBL18642506 | 0.77 | SCN5A (0.45) | SCN5APDPK1NOTUMCHEK1GRM2 | |
| SCHEMBL18632526 | 0.76 | SCN5A (0.47) | SCN5APDPK1NOTUMCHEK1GRM2 | |
| SCHEMBL18632511 | 0.73 | LTK (0.55) | SCN5ANOTUMCHEK1GRM2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170081323-A1 | Triazolones derivatives for use in the treatment, amelioration or prevention of a viral disease | HOFFMANN LA ROCHE (CH) | 2017-03-23 | — | — | US | disclosed |
| US-20170081323-A1 | Triazolones derivatives for use in the treatment, amelioration or prevention of a viral disease | HOFFMANN LA ROCHE (CH) | 2017-03-23 | — | — | US | disclosed |
| US-20170081323-A1 | Triazolones derivatives for use in the treatment, amelioration or prevention of a viral disease | HOFFMANN LA ROCHE (CH) | 2017-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170081323-A1 | Triazolones derivatives for use in the treatment, amelioration or prevention of a viral disease | OAT, XDH, MAPT | SCN5A 1311/4885PDPK1 2343/4885NOTUM 541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.