Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15106846 | 0.90 | EGFR (0.61) | EGFRKDREPHA2EPHB4ERBB2 | |
| SCHEMBL18633147 | 0.83 | EGFR (0.59) | EGFRKDRFLT1EPHA2EPHB4 | |
| SCHEMBL15090717 | 0.80 | EGFR (0.73) | EGFRKDREPHA2EPHB4ERBB2 | |
| SCHEMBL15090694 | 0.78 | EGFR (0.59) | EGFR | |
| SCHEMBL18862763 | 0.77 | EGFR (0.60) | EGFRKDRFLT1EPHB4ERBB2 | |
| SCHEMBL19628577 | 0.77 | EGFR (0.69) | EGFRERBB2 | |
| SCHEMBL15090755 | 0.75 | EGFR (0.82) | EGFRKDRFLT1EPHB4ERBB2 | |
| SCHEMBL14388074 | 0.74 | EGFR (0.51) | EGFRKDRFLT1EPHA2EPHB4 | |
| SCHEMBL18633113 | 0.74 | EGFR (0.58) | EGFRKDRFLT1EPHA2EPHB4 | |
| SCHEMBL14388230 | 0.74 | EGFR (0.41) | EGFRKDREPHB4ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2612860-B1 | QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF | XUANZHU PHARMA CO LTD (CN) | 2017-03-15 | — | — | EP | disclosed |