Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.59 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | FLT1 | P17948 | 2/20 | 0.45 |
| ▸ | FLT4 | P35916 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | KIF5B | P33176 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL255527 | 0.89 | EGFR (0.72) | EGFRKDREPHA2EPHB4FLT4 | |
| SCHEMBL18633148 | 0.84 | EGFR (0.71) | EGFR | |
| SCHEMBL18633102 | 0.83 | EGFR (0.51) | EGFRKDREPHA2EPHB4FGFR1 | |
| SCHEMBL18633014 | 0.82 | EGFR (0.69) | EGFR | |
| SCHEMBL15100019 | 0.81 | EGFR (0.73) | EGFR | |
| SCHEMBL18633015 | 0.81 | EGFR (0.67) | EGFRRET | |
| SCHEMBL18633004 | 0.81 | EGFR (0.50) | EGFRKDREPHA2EPHB4FLT4 | |
| SCHEMBL18633151 | 0.80 | EGFR (0.58) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL256543 | 0.79 | EGFR (0.59) | EGFRKDREPHA2EPHB4FLT4 | |
| SCHEMBL15090717 | 0.79 | EGFR (0.73) | EGFRKDREPHA2EPHB4FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2612860-B1 | QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF | XUANZHU PHARMA CO LTD (CN) | 2017-03-15 | — | — | EP | disclosed |