Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
| ▸ | FLT4 | P35916 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15090813 | 0.90 | EGFR (0.71) | EGFR | |
| SCHEMBL18633111 | 0.84 | EGFR (0.57) | EGFRFBP1 | |
| SCHEMBL18633146 | 0.83 | EGFR (0.46) | EGFRKDRFBP1 | |
| SCHEMBL15090622 | 0.83 | EGFR (0.70) | EGFRKDRFBP1 | |
| SCHEMBL18633147 | 0.80 | EGFR (0.59) | EGFRFGFR1FLT1FLT4KDR | |
| SCHEMBL15090653 | 0.80 | EGFR (0.71) | EGFR | |
| SCHEMBL18862789 | 0.79 | EGFR (0.63) | EGFRFLT4KDRFBP1 | |
| SCHEMBL15100019 | 0.78 | EGFR (0.73) | EGFR | |
| SCHEMBL15100099 | 0.77 | EGFR (0.58) | EGFRFLT1KDRFBP1 | |
| SCHEMBL14387983 | 0.77 | EGFR (0.48) | EGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2612860-B1 | QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF | XUANZHU PHARMA CO LTD (CN) | 2017-03-15 | — | — | EP | disclosed |