Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15759992 | 0.67 | MAPT (0.61) | MAPTALDH1A1POLBALDH3A1CYP3A4 | |
| SCHEMBL12218459 | 0.64 | MAPT (0.62) | MAPTALDH1A1POLBCYP3A4CYP2C9 | |
| SCHEMBL10390687 | 0.62 | CYP3A4 (0.53) | MAPTALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1521528 | 0.62 | MAPT (0.52) | MAPTALDH1A1POLBALDH3A1CYP2C19 | |
| SCHEMBL7128898 | 0.61 | HTR6 (0.62) | MAPTALDH1A1POLBALDH3A1GAA | |
| SCHEMBL11526512 | 0.61 | CYP3A4 (0.62) | MAPTALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL18956811 | 0.60 | MAPT (0.51) | MAPTALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL27543438 | 0.60 | CYP3A4 (0.57) | MAPTALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL15363559 | 0.60 | CYP2C9 (0.61) | MAPTALDH1A1POLBCYP3A4CYP2C9 | |
| SCHEMBL16645403 | 0.60 | CYP2C9 (0.61) | MAPTALDH1A1POLBCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2612860-B1 | QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF | XUANZHU PHARMA CO LTD (CN) | 2017-03-15 | — | — | EP | disclosed |