Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.47 |
| ▸ | MASP2 | O00187 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | PIR | O00625 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.37 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | STK16 | O75716 | 1/20 | 0.37 |
| ▸ | OXSR1 | O95747 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | FES | P07332 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1863382 | 1.00 | BRAF (0.47) | BRAFMASP2KLKB1NAMPTBMPR1B | |
| SCHEMBL1870117 | 0.91 | BRAF (0.47) | BRAFMASP2KLKB1NAMPTABL1 | |
| SCHEMBL1870114 | 0.91 | BRAF (0.47) | BRAFMASP2KLKB1NAMPTABL1 | |
| SCHEMBL1861630 | 0.90 | BRAF (0.45) | BRAFMASP2KLKB1NAMPTFLT3 | |
| SCHEMBL1861627 | 0.90 | BRAF (0.45) | BRAFMASP2KLKB1NAMPTFLT3 | |
| SCHEMBL1867508 | 0.89 | BRAF (0.46) | BRAFMASP2NAMPTPLK4DCLK1 | |
| SCHEMBL1867506 | 0.89 | BRAF (0.46) | BRAFMASP2NAMPTPLK4DCLK1 | |
| SCHEMBL1865731 | 0.89 | KLKB1 (0.45) | BRAFMASP2KLKB1NAMPTFLT3 | |
| SCHEMBL1865734 | 0.89 | KLKB1 (0.45) | BRAFMASP2KLKB1NAMPTFLT3 | |
| SCHEMBL1867774 | 0.88 | BRAF (0.47) | BRAFMASP2KLKB1NAMPTFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051672-A1 | AZAINDOLE DERIVATIVES | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |