Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | SLC15A1 | P46059 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18634625 | 1.00 | AAK1 (0.47) | AAK1SYKSLC15A1ALDH1A1MAPK1 | |
| SCHEMBL8219512 | 0.87 | SYK (0.44) | SYKSLC15A1ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL973865 | 0.87 | CA2 (0.47) | SYKSLC15A1ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL18634633 | 0.87 | CA2 (0.47) | SYKSLC15A1ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL8219511 | 0.87 | SYK (0.44) | SYKSLC15A1ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL7536206 | 0.86 | FOLH1 (0.47) | SYKSLC15A1ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL8218736 | 0.85 | SYK (0.45) | SYKALDH1A1MAPK1L3MBTL1MAPT | |
| SCHEMBL8218735 | 0.85 | SYK (0.45) | SYKALDH1A1MAPK1L3MBTL1MAPT | |
| SCHEMBL7280308 | 0.84 | SLC15A1 (0.49) | SYKSLC15A1ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL28638619 | 0.84 | SYK (0.45) | SYKSLC15A1ALDH1A1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897938-B1 | FLUOROALKYL DIBENZODIAZEPINONE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-03-15 | — | — | EP | disclosed |