Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 3/20 | 0.47 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 11/20 | 0.44 |
| ▸ | BRD2 | P25440 | 4/20 | 0.44 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16110759 | 0.85 | BRD4 (0.44) | FTOATAD2BRD4BRD2BRD3 | |
| SCHEMBL17773292 | 0.85 | ATAD2 (0.44) | FTOATAD2BRD4BRD2BRD3 | |
| SCHEMBL16225362 | 0.85 | FTO (0.51) | FTOATAD2BRD4BRD2ERN1 | |
| SCHEMBL20362718 | 0.81 | BRD4 (0.49) | FTOATAD2BRD4BRD2BRD3 | |
| SCHEMBL16110862 | 0.79 | ATAD2 (0.59) | FTOATAD2BRD4BRD2ERN1 | |
| SCHEMBL20362753 | 0.76 | ERN1 (0.56) | FTOATAD2BRD4BRD2BRD3 | |
| SCHEMBL16132371 | 0.76 | FTO (0.55) | FTOATAD2BRD4BRD2ERN1 | |
| SCHEMBL22855856 | 0.76 | JAK2 (0.51) | BRD4BRD2BRD3ERN1LMNA | |
| SCHEMBL19726803 | 0.75 | BRD4 (0.51) | ATAD2BRD4BRD2CYP1A2MEN1 | |
| SCHEMBL22497644 | 0.74 | BRD4 (0.61) | BRD4BRD2BRD3ERN1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2978759-B1 | BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES INC (US) | 2017-03-15 | — | — | EP | disclosed |