Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18559449 | 1.00 | NR1I2 (0.46) | NR1I2MAPTALDH1A1POLBNAAA | |
| SCHEMBL9227794 | 1.00 | NR1I2 (0.46) | NR1I2MAPTALDH1A1POLBNAAA | |
| SCHEMBL9227674 | 1.00 | NR1I2 (0.46) | NR1I2MAPTALDH1A1POLBNAAA | |
| SCHEMBL3443068 | 1.00 | NR1I2 (0.46) | NR1I2MAPTALDH1A1POLBNAAA | |
| SCHEMBL19513573 | 1.00 | NR1I2 (0.46) | NR1I2MAPTALDH1A1POLBNAAA | |
| SCHEMBL18559615 | 1.00 | NR1I2 (0.46) | NR1I2MAPTALDH1A1POLBNAAA | |
| SCHEMBL18638701 | 0.98 | NR1I2 (0.45) | NR1I2MAPTALDH1A1POLBNAAA | |
| SCHEMBL19225149 | 0.98 | NR1I2 (0.45) | NR1I2MAPTALDH1A1POLBNAAA | |
| SCHEMBL18559574 | 0.98 | ALDH1A1 (0.46) | NR1I2MAPTALDH1A1POLBNAAA | |
| SCHEMBL23371800 | 0.96 | NR1I2 (0.44) | NR1I2MAPTALDH1A1POLBNAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10479795-B2 | Substituted imidazo[2,1-f][1,2,4]triazines, substituted imidazo[1,2-a]pyridines and substituted imidazo[1,2-b]pyridazines as PI3K-gamma inhibitors | INCYTE CORPORATION (US) | 2019-11-19 | — | — | US | disclosed |
| US-20190119287-A1 | HETEROCYCLIC COMPOUNDS AS PI3K-y INHIBITORS | INCYTE CORPORATION | 2019-04-25 | — | — | US | disclosed |
| US-20190112305-A1 | BONE MARROW ON X CHROMOSOME KINASE (BMX) INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-04-18 | — | — | US | disclosed |
| US-10023536-B2 | Suprametallogels and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2018-07-17 | — | — | US | disclosed |
| US-20170073311-A1 | SUPRAMETALLOGELS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2017-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10479795-B2 | Substituted imidazo[2,1-f][1,2,4]triazines, substituted imidazo[1,2-a]pyridines and substituted imidazo[1,2-b]pyridazines as PI3K-gamma inhibitors | PIK3CG, PIK3CD, PIK3CA | NR1I2 364/4885MAPT 3504/4885ALDH1A1 1354/4885 |
| US-10023536-B2 | Suprametallogels and uses thereof | PDCD1LG2, PDCD2L, PYGL | NR1I2 2161/4885MAPT 3850/4885ALDH1A1 912/4885 |
| US-20190112305-A1 | BONE MARROW ON X CHROMOSOME KINASE (BMX) INHIBITORS AND USES THEREOF | BMX, MELK, TEC | NR1I2 1386/4885MAPT 992/4885ALDH1A1 4530/4885 |
| US-20190119287-A1 | HETEROCYCLIC COMPOUNDS AS PI3K-y INHIBITORS | PIK3R5, PIK3CA, PIK3CD | NR1I2 1291/4885MAPT 3639/4885ALDH1A1 3638/4885 |
| US-20170073311-A1 | SUPRAMETALLOGELS AND USES THEREOF | PDCD1LG2, PDCD2L, PYGL | NR1I2 2161/4885MAPT 3850/4885ALDH1A1 912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.