SCHEMBL18636612

SCHEMBL18636612

O[C@H]1CO[C@H](COCc2ccccc2)C1

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.48
TAAR1 Q96RJ0 1/20 0.44
SLC6A2 P23975 1/20 0.43
TSHR P16473 1/20 0.42
DRD1 P21728 1/20 0.41
BACE1 P56817 1/20 0.41
HRH4 Q9H3N8 4/20 0.40
HRH3 Q9Y5N1 4/20 0.40
PDE4D Q08499 1/20 0.40
PTPN1 P18031 1/20 0.39
CDC25B P30305 1/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
MGLL Q99685 1/20 0.38
BCHE P06276 1/20 0.38
ACHE P22303 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25308921 1.00 LMNA (0.48) LMNATAAR1SLC6A2TSHRDRD1
SCHEMBL1564708 0.88 LMNA (0.46) LMNATAAR1SLC6A2TSHRDRD1
SCHEMBL15419089 0.88 LMNA (0.46) LMNATAAR1SLC6A2TSHRDRD1
SCHEMBL18535611 0.88 LMNA (0.46) LMNATAAR1SLC6A2TSHRDRD1
SCHEMBL1566210 0.88 LMNA (0.46) LMNATAAR1SLC6A2TSHRDRD1
SCHEMBL1566074 0.88 LMNA (0.48) LMNATAAR1SLC6A2TSHRDRD1
SCHEMBL25309758 0.88 LMNA (0.48) LMNATAAR1SLC6A2TSHRDRD1
SCHEMBL417603 0.88 LMNA (0.48) LMNATAAR1SLC6A2TSHRDRD1
SCHEMBL25308726 0.88 LMNA (0.48) LMNATAAR1SLC6A2TSHRDRD1
SCHEMBL306297 0.81 LMNA (0.57) LMNATAAR1TSHRDRD1HRH4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230125751-A1 METHODS AND COMPOUNDS FOR TREATING PARAMYXOVIRIDAE VIRUS INFECTIONS GILEAD SCIENCES, INC. 2023-04-27 US disclosed
US-20230027727-A1 METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS GILEAD SCIENCES, INC. 2023-01-26 US disclosed
US-11382926-B2 Methods for treating Arenaviridae and Coronaviridae virus infections GILEAD SCIENCES, INC. (US) 2022-07-12 US disclosed
US-20210393659-A1 METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS GILEAD SCIENCES, INC. 2021-12-23 US disclosed
US-11007208-B2 Methods for treating arenaviridae and coronaviridae virus infections GILEAD SCIENCES, INC. (US) 2021-05-18 US disclosed
US-20210061806-A1 METHODS AND COMPOUNDS FOR TREATING PARAMYXOVIRIDAE VIRUS INFECTIONS GILEAD SCIENCES, INC. 2021-03-04 US disclosed
US-20200352967-A1 METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS GILEAD SCIENCES, INC. 2020-11-12 US disclosed
US-10695361-B2 Methods for treating arenaviridae and coronaviridae virus infections GILEAD SCIENCES, INC. (US) 2020-06-30 US disclosed
US-20200197422-A1 METHODS FOR THE PREPARATION OF RIBOSIDES GILEAD SCIENCES, INC. 2020-06-25 US disclosed
US-20190255085-A1 METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS GILEAD SCIENCES, INC. 2019-08-22 US disclosed
US-10251904-B2 Methods for treating arenaviridae and coronaviridae virus infections GILEAD SCIENCES, INC. (US) 2019-04-09 US disclosed
WO-2017049060-A1 METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS GILEAD SCIENCES, INC. (US) 2017-03-23 WO disclosed
US-20170071964-A1 METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS GILEAD SCIENCES, INC. 2017-03-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210061806-A1 METHODS AND COMPOUNDS FOR TREATING PARAMYXOVIRIDAE VIRUS INFECTIONS PNP, RPIA, HPRT1 LMNA 1211/4885TAAR1 4863/4885SLC6A2 2565/4885
US-10251904-B2 Methods for treating arenaviridae and coronaviridae virus infections ACE, PNP, ACE2 LMNA 1684/4885TAAR1 3974/4885SLC6A2 2510/4885
US-10695361-B2 Methods for treating arenaviridae and coronaviridae virus infections ACE, PNP, ACE2 LMNA 1684/4885TAAR1 3974/4885SLC6A2 2510/4885
US-11007208-B2 Methods for treating arenaviridae and coronaviridae virus infections ACE, PNP, ACE2 LMNA 1684/4885TAAR1 3974/4885SLC6A2 2510/4885
US-11382926-B2 Methods for treating Arenaviridae and Coronaviridae virus infections ACE, PNP, ACE2 LMNA 1684/4885TAAR1 3974/4885SLC6A2 2510/4885
US-20230125751-A1 METHODS AND COMPOUNDS FOR TREATING PARAMYXOVIRIDAE VIRUS INFECTIONS PNP, RPIA, HPRT1 LMNA 1211/4885TAAR1 4863/4885SLC6A2 2565/4885
US-20190255085-A1 METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS ACE, PNP, ACE2 LMNA 1684/4885TAAR1 3974/4885SLC6A2 2510/4885
US-20210393659-A1 METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS ACE, PNP, ACE2 LMNA 1684/4885TAAR1 3974/4885SLC6A2 2510/4885
US-20170071964-A1 METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS ACE, PNP, ACE2 LMNA 1684/4885TAAR1 3974/4885SLC6A2 2510/4885
US-20200352967-A1 METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS ACE, PNP, ACE2 LMNA 1684/4885TAAR1 3974/4885SLC6A2 2510/4885
US-20200197422-A1 METHODS FOR THE PREPARATION OF RIBOSIDES PRPS1, PRPF4, PRPF31 LMNA 205/4885TAAR1 4088/4885SLC6A2 1869/4885
US-20230027727-A1 METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS PNP, ACE, ACE2 LMNA 1620/4885TAAR1 3918/4885SLC6A2 2470/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.