Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | STING1 | Q86WV6 | 3/20 | 0.35 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.34 |
| ▸ | POLRMT | O00411 | 1/20 | 0.34 |
| ▸ | NADK | O95544 | 1/20 | 0.33 |
| ▸ | ATG7 | O95352 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26251486 | 0.88 | CA12 (0.37) | CA12CA1CA2CA9STING1 | |
| SCHEMBL26254436 | 0.87 | CA12 (0.36) | CA12CA1CA2CA9STING1 | |
| SCHEMBL18636645 | 0.87 | CA12 (0.41) | CA12CA1CA2CA9POLRMT | |
| SCHEMBL22646509 | 0.84 | CA12 (0.39) | CA12CA1CA2CA9POLRMT | |
| SCHEMBL13667664 | 0.81 | CA12 (0.37) | CA12CA1CA2CA9STING1 | |
| SCHEMBL22096273 | 0.79 | CA12 (0.36) | CA12CA1CA2CA9STING1 | |
| SCHEMBL19779075 | 0.79 | POLRMT (0.46) | CA12CA1CA2CA9STING1 | |
| SCHEMBL18666929 | 0.79 | CA12 (0.38) | CA12CA1CA2CA9STING1 | |
| SCHEMBL26251633 | 0.78 | STING1 (0.34) | STING1DOT1LPOLRMT | |
| SCHEMBL16710702 | 0.78 | POLRMT (0.40) | CA12CA1CA2CA9STING1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11382926-B2 | Methods for treating Arenaviridae and Coronaviridae virus infections | GILEAD SCIENCES, INC. (US) | 2022-07-12 | — | — | US | disclosed |
| US-20210393659-A1 | METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS | GILEAD SCIENCES, INC. | 2021-12-23 | — | — | US | disclosed |
| US-10251904-B2 | Methods for treating arenaviridae and coronaviridae virus infections | GILEAD SCIENCES, INC. (US) | 2019-04-09 | — | — | US | disclosed |
| US-20170071964-A1 | METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS | GILEAD SCIENCES, INC. | 2017-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10251904-B2 | Methods for treating arenaviridae and coronaviridae virus infections | ACE, PNP, ACE2 | CA12 2132/4885CA1 2531/4885CA2 3752/4885 |
| US-11382926-B2 | Methods for treating Arenaviridae and Coronaviridae virus infections | ACE, PNP, ACE2 | CA12 2132/4885CA1 2531/4885CA2 3752/4885 |
| US-20210393659-A1 | METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS | ACE, PNP, ACE2 | CA12 2132/4885CA1 2531/4885CA2 3752/4885 |
| US-20170071964-A1 | METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS | ACE, PNP, ACE2 | CA12 2132/4885CA1 2531/4885CA2 3752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.