Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.55 |
| ▸ | AURKA | O14965 | 6/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 6/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.49 |
| ▸ | BTK | Q06187 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18636734 | 0.83 | LMNA (0.53) | HRH4AURKAPDPK1AURKBBTK | |
| SCHEMBL18636586 | 0.83 | HRH4 (0.54) | HRH4AURKAPDPK1AURKBBTK | |
| SCHEMBL18636769 | 0.82 | HRH4 (0.69) | HRH4AURKAPDPK1AURKBBTK | |
| SCHEMBL12604979 | 0.81 | HRH4 (0.48) | HRH4AURKAPDPK1AURKBJAK3 | |
| SCHEMBL12605055 | 0.78 | HRH4 (0.81) | HRH4HRH3 | |
| SCHEMBL14428134 | 0.76 | AURKA (0.52) | AURKAPDPK1AURKBBTKJAK3 | |
| SCHEMBL26349780 | 0.76 | AURKA (0.63) | HRH4AURKAPDPK1AURKBBTK | |
| SCHEMBL26349862 | 0.76 | AURKA (0.63) | HRH4AURKAPDPK1AURKBBTK | |
| SCHEMBL12118769 | 0.76 | AURKA (0.63) | AURKAPDPK1AURKBBTKJAK3 | |
| SCHEMBL16977369 | 0.76 | AURKA (0.63) | AURKAPDPK1AURKBBTKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966162-B1 | PYRIMIDINE DERIVATIVES | ZIARCO PHARMA LTD (GB) | 2017-03-15 | — | — | EP | disclosed |