Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 6/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 6/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.52 |
| ▸ | BTK | Q06187 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.42 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12119818 | 0.91 | AURKA (0.63) | LMNAAURKAPDPK1AURKBBTK | |
| SCHEMBL31741685 | 0.91 | LMNA (0.57) | LMNAAURKAPDPK1AURKBBTK | |
| SCHEMBL16977369 | 0.89 | AURKA (0.63) | LMNAAURKAPDPK1AURKBBTK | |
| SCHEMBL12118769 | 0.89 | AURKA (0.63) | LMNAAURKAPDPK1AURKBBTK | |
| SCHEMBL27717380 | 0.88 | LMNA (0.60) | LMNAAURKAPDPK1AURKBHRH3 | |
| SCHEMBL27738450 | 0.83 | LMNA (0.53) | LMNAPDE10AHRH3HRH4CYP1A2 | |
| SCHEMBL18636729 | 0.83 | HRH4 (0.55) | AURKAPDPK1AURKBBTKJAK3 | |
| SCHEMBL12119179 | 0.82 | AURKA (0.63) | LMNAAURKAPDPK1AURKBBTK | |
| SCHEMBL12119518 | 0.82 | AURKA (0.63) | LMNAAURKAPDPK1AURKBBTK | |
| SCHEMBL3196818 | 0.82 | LMNA (0.56) | LMNAHRH3HRH4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966162-B1 | PYRIMIDINE DERIVATIVES | ZIARCO PHARMA LTD (GB) | 2017-03-15 | — | — | EP | disclosed |