SCHEMBL1863702

SCHEMBL1863702

Cc1nc(N2CCNCC2)nc2c1CC(=O)C(C)N2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 9/20 0.38
ALDH1A1 P00352 9/20 0.38
CYP1A2 P05177 8/20 0.38
CASP7 P55210 8/20 0.38
HSD17B10 Q99714 7/20 0.38
HPGD P15428 6/20 0.38
CYP3A4 P08684 4/20 0.38
CYP2C19 P33261 2/20 0.38
TSHR P16473 2/20 0.38
HRH1 P35367 1/20 0.38
USP2 O75604 5/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
CASP4 P49662 1/20 0.34
CASP5 P51878 1/20 0.34
HTR2C P28335 1/20 0.34
ROCK2 O75116 1/20 0.31
KDM4E B2RXH2 2/20 0.30
MEN1 O00255 1/20 0.30
CYP2C9 P11712 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1847166 0.69 ALDH1A1 (0.43) CASP1ALDH1A1CYP1A2CASP7HSD17B10
SCHEMBL9488077 0.68 HRH1 (0.59) CASP1ALDH1A1CYP1A2CASP7HSD17B10
Hydrochloric Acid SCHEMBL8809398 0.68 ALDH1A1 (0.42) CASP1ALDH1A1CYP1A2CASP7HSD17B10
Hydrochloric Acid SCHEMBL8582704 0.66 HRH1 (0.57) CASP1ALDH1A1CYP1A2CASP7HSD17B10
SCHEMBL10512778 0.64 HTR2C (0.68) CASP1ALDH1A1CYP1A2HPGDHRH1
SCHEMBL1229731 0.63 HRH1 (0.85) CASP1ALDH1A1HPGDHRH1USP2
SCHEMBL6027662 0.62 HRH1 (0.61) CASP1ALDH1A1CYP1A2CASP7HSD17B10
SCHEMBL10028669 0.61 HRH1 (0.65) CASP1ALDH1A1HPGDHRH1USP2
SCHEMBL1845633 0.60 HRH1 (0.41) CASP1ALDH1A1CYP1A2CASP7HSD17B10
SCHEMBL1515373 0.60 CASP1 (0.58) CASP1ALDH1A1CYP1A2CASP7HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2324023-A1 VIGOR ENHANCEMENT VIA ADMINISTRATION OF PYRIMIDINE DERIVATIVES UNIVERSITY OF CENTRAL FLORIDA (US) 2011-05-25 EP disclosed
WO-2009070164-A1 VIGOR ENHANCEMENT VIA ADMINISTRATION OF PYRIMIDINE DERIVATIVES UNIVERSITY OF CENTRAL FLORIDA (US) 2009-06-04 WO disclosed