Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.36 |
| ▸ | FAAH | O00519 | 4/20 | 0.36 |
| ▸ | FPR2 | P25090 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186807 | 0.92 | RAB9A (0.38) | RAB9ANPC1TRPV1FAAHSMN1; SMN2 | |
| SCHEMBL2808283 | 0.89 | RAB9A (0.41) | RAB9ANPC1FPR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL14856806 | 0.89 | TRPV1 (0.36) | RAB9ANPC1TRPV1FAAHFPR2 | |
| SCHEMBL185951 | 0.86 | TRPV1 (0.33) | NPC1TRPV1FAAHFPR2BDKRB1 | |
| SCHEMBL185551 | 0.81 | CNR2 (0.33) | TRPV1FAAHFPR2 | |
| SCHEMBL13128603 | 0.81 | BDKRB1 (0.43) | RAB9ABDKRB1 | |
| SCHEMBL2807389 | 0.80 | BDKRB1 (0.42) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL14856784 | 0.80 | FAAH (0.36) | NPC1TRPV1FAAHKMT2AMEN1 | |
| SCHEMBL13128606 | 0.80 | BDKRB1 (0.42) | BDKRB1 | |
| SCHEMBL14856682 | 0.79 | FAAH (0.36) | TRPV1FAAHFPR2BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |