Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 5/20 | 0.73 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.73 |
| ▸ | DRD2 | P14416 | 16/20 | 0.73 |
| ▸ | DRD1 | P21728 | 8/20 | 0.73 |
| ▸ | DRD4 | P21917 | 3/20 | 0.73 |
| ▸ | DRD3 | P35462 | 3/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.73 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.73 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.73 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.73 |
| ▸ | DRD5 | P21918 | 2/20 | 0.73 |
| ▸ | HRH1 | P35367 | 2/20 | 0.73 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.73 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29447350 | 0.90 | DRD2 (0.72) | DRD2DRD1CHRM1DRD4DRD3 | |
| SCHEMBL18257470 | 0.90 | DRD2 (0.72) | DRD2DRD1CHRM1DRD4DRD3 | |
| SCHEMBL29898495 | 0.90 | DRD2 (0.72) | DRD2DRD1CHRM1DRD4DRD3 | |
| SCHEMBL9014028 | 0.90 | DRD2 (0.72) | DRD2DRD1CHRM1DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL30464869 | 0.89 | DRD2 (0.71) | DRD2DRD1CHRM1DRD4DRD3 | |
| SCHEMBL20887469 | 0.88 | DRD2 (0.88) | DRD2DRD1CHRM1DRD4DRD3 | |
| Clozapine SCHEMBL8397 | 0.85 | DRD2 (1.00) | DRD2DRD1CHRM1DRD4DRD3 | |
| Clozapine SCHEMBL5501558 | 0.85 | DRD2 (1.00) | DRD2DRD1CHRM1DRD4DRD3 | |
| Clozapine SCHEMBL20876213 | 0.85 | DRD2 (1.00) | DRD2DRD1CHRM1DRD4DRD3 | |
| Clozapine SCHEMBL29360001 | 0.85 | DRD2 (1.00) | DRD2DRD1CHRM1DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3349760-A1 | COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS | Coda Biotherapeutics, Inc. (US) | 2018-07-25 | — | — | EP | claimed |
| WO-2017049252-A1 | COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS | SWITCH BIO, INC. (US) | 2017-03-23 | — | — | WO | claimed |
| EP-3349760-A1 | COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS | Coda Biotherapeutics, Inc. (US) | 2018-07-25 | — | — | EP | disclosed |
| US-20180193414-A1 | COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS | CODA BIOTHERAPEUTICS INC (US) | 2018-07-12 | — | — | US | disclosed |
| WO-2017049252-A1 | COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS | SWITCH BIO, INC. (US) | 2017-03-23 | — | — | WO | disclosed |