Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 16/20 | 0.72 |
| ▸ | DRD1 | P21728 | 8/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.72 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.72 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.72 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.72 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.72 |
| ▸ | DRD4 | P21917 | 3/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.72 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.72 |
| ▸ | DRD3 | P35462 | 2/20 | 0.72 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.72 |
| ▸ | HTR2A | P28223 | 2/20 | 0.72 |
| ▸ | HTR2C | P28335 | 2/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.72 |
| ▸ | HRH1 | P35367 | 2/20 | 0.72 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014028 | 1.00 | DRD2 (0.72) | DRD2DRD1CHRM1CHRM2CHRM4 | |
| SCHEMBL29447350 | 1.00 | DRD2 (0.72) | DRD2DRD1CHRM1CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL30464869 | 0.99 | DRD2 (0.71) | DRD2DRD1CHRM1CHRM2CHRM4 | |
| Iodide SCHEMBL18639888 | 0.90 | DRD2 (0.73) | DRD2DRD1CHRM1CHRM2CHRM4 | |
| SCHEMBL18257470 | 0.89 | DRD2 (0.72) | DRD2DRD1CHRM1CHRM2CHRM4 | |
| SCHEMBL20887469 | 0.87 | DRD2 (0.88) | DRD2DRD1CHRM1CHRM2CHRM4 | |
| SCHEMBL3411429 | 0.85 | DRD2 (0.78) | DRD2DRD1CHRM1CHRM2CHRM4 | |
| Clozapine SCHEMBL8397 | 0.84 | DRD2 (1.00) | DRD2DRD1CHRM1CHRM2CHRM4 | |
| Clozapine SCHEMBL5501558 | 0.84 | DRD2 (1.00) | DRD2DRD1CHRM1CHRM2CHRM4 | |
| Clozapine SCHEMBL20876213 | 0.84 | DRD2 (1.00) | DRD2DRD1CHRM1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118807068-A | Novel targets for the treatment or diagnosis of mood disorders or stress disorders and uses thereof | 浙江大学 | 2024-10-22 | — | — | CN | disclosed |
| WO-2023202682-A1 | NOVEL TARGET FOR TREATING OR DIAGNOSING EMOTIONAL DISORDERS OR STRESS DISORDERS, AND APPLICATION THEREOF | 浙江大学 | 2023-10-26 | — | — | WO | disclosed |
| CN-115141803-B | Method for obtaining myeloglutamatergic interneurons by induction of human pluripotent stem cells and application thereof | 武汉泓宸创新生物科技有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-116672466-A | Application of M1 zone neuron activity inhibitor in preparation of ischemic cerebral apoplexy prevention and treatment drugs | 山东大学 | 2023-09-01 | — | — | CN | disclosed |
| WO-2023108485-A1 | METHOD FOR REGULATING HETEROGENEITY OF VASCULAR ENDOTHELIAL CELLS BY MEANS OF LOCUS COERULEUS AND PERIPHERAL REGION THEREOF | 中国科学院深圳先进技术研究院 | 2023-06-22 | — | — | WO | disclosed |
| WO-2023019565-A1 | METHOD FOR CONTROLLING HETEROGENEITY OF VASCULAR ENDOTHELIAL CELLS BY USING SYMPATHETIC NERVES | 中国科学院深圳先进技术研究院 | 2023-02-23 | — | — | WO | disclosed |
| CN-115141803-A | Method for obtaining glutamatergic interneurons of spinal cord by inducing human pluripotent stem cells and application thereof | 华中科技大学同济医学院附属同济医院 | 2022-10-04 | — | — | CN | disclosed |