Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 13/20 | 0.56 |
| ▸ | MAOA | P21397 | 5/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13736416 | 0.89 | KIT (0.54) | MAOB | |
| SCHEMBL18639944 | 0.83 | MAOB (0.47) | MAOBMAOAAR | |
| SCHEMBL18639883 | 0.83 | MAOB (0.49) | MAOBMAOAAR | |
| SCHEMBL18640073 | 0.83 | IKBKE (0.43) | MAOA | |
| SCHEMBL216014 | 0.83 | CNR2 (0.54) | MAOB | |
| SCHEMBL11963403 | 0.82 | IKBKE (0.54) | MAOBMAOA | |
| SCHEMBL18639882 | 0.80 | MAOA (0.50) | MAOBMAOAAR | |
| SCHEMBL18640122 | 0.78 | CYP2D6 (0.51) | MAOBMAOA | |
| SCHEMBL18639861 | 0.78 | MAPK1 (0.50) | MAOBMAOA | |
| SCHEMBL13736786 | 0.77 | KIT (0.55) | MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017045751-A1 | COMPOUNDS AS ASIC INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-03-23 | — | — | WO | disclosed |
| WO-2017045751-A1 | COMPOUNDS AS ASIC INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-03-23 | — | — | WO | disclosed |