Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18640221 | 0.99 | KCNH2 (0.53) | KCNH2TACR1KMT2ASPHK1 | |
| SCHEMBL18640359 | 0.96 | KCNH2 (0.46) | KCNH2TACR1CCR3 | |
| SCHEMBL18640284 | 0.91 | TACR1 (0.47) | KCNH2TACR1 | |
| SCHEMBL11788316 | 0.84 | KCNH2 (0.51) | KCNH2KMT2ASPHK1CCR3 | |
| SCHEMBL18640256 | 0.82 | TACR1 (0.47) | TACR1CCR3 | |
| SCHEMBL18640337 | 0.82 | OPRK1 (0.45) | TACR1 | |
| SCHEMBL11404739 | 0.81 | KCNH2 (0.56) | KCNH2SPHK1 | |
| SCHEMBL8925928 | 0.80 | TACR1 (0.50) | TACR1CCR3 | |
| SCHEMBL3652328 | 0.80 | TACR1 (0.50) | TACR1CCR3 | |
| SCHEMBL8925926 | 0.80 | TACR1 (0.50) | TACR1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3349743-A1 | METHODS AND COMPOSITIONS OF INHIBITING DCN1-UBC12 INTERACTION | St. Jude Children's Research Hospital (US) | 2018-07-25 | — | — | EP | disclosed |
| WO-2017049295-A1 | METHODS AND COMPOSITIONS OF INHIBITING DCN1-UBC12 INTERACTION | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2017-03-23 | — | — | WO | disclosed |