Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 3/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.36 |
| ▸ | BUB1 | O43683 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | STS | P08842 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185246 | 0.87 | BUB1 (0.42) | CCR4GRIN1GRIN2BROCK2BUB1 | |
| SCHEMBL186311 | 0.85 | GRIN1 (0.42) | CCR4GRIN1GRIN2BROCK2BUB1 | |
| SCHEMBL185923 | 0.82 | RORC (0.46) | CCR4GRIN1GRIN2B | |
| SCHEMBL185631 | 0.80 | CCR4 (0.41) | CCR4GRIN1GRIN2BROCK2BUB1 | |
| SCHEMBL186432 | 0.77 | CCR4 (0.56) | CCR4 | |
| SCHEMBL185667 | 0.77 | RORC (0.36) | CCR4GRIN1GRIN2BBUB1CYP19A1 | |
| SCHEMBL186084 | 0.74 | CCR4 (0.52) | CCR4 | |
| SCHEMBL186961 | 0.70 | CCR4 (0.44) | CCR4 | |
| SCHEMBL185344 | 0.69 | CCR4 (0.43) | CCR4 | |
| SCHEMBL185375 | 0.69 | CCR4 (0.43) | CCR4BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401270-A1 | PYRAZOLE DERIVATIVES USED AS CCR4 RECEPTOR ANTAGONISTS | Glaxo Group Limited (GB) | 2012-01-04 | — | — | EP | disclosed |