Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 17/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | CCR4 | P51679 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185667 | 0.89 | RORC (0.36) | RORCFEN1GRIN1GRIN2BCCR4 | |
| SCHEMBL185246 | 0.87 | BUB1 (0.42) | GRIN1GRIN2BCCR4 | |
| SCHEMBL186311 | 0.84 | GRIN1 (0.42) | FEN1GRIN1GRIN2BCCR4 | |
| SCHEMBL186431 | 0.82 | CCR4 (0.41) | GRIN1GRIN2BCCR4 | |
| SCHEMBL186021 | 0.77 | GRIN1 (0.44) | RORCGRIN1GRIN2B | |
| SCHEMBL185924 | 0.74 | CCR4 (0.51) | CCR4 | |
| SCHEMBL186084 | 0.73 | CCR4 (0.52) | RORCCCR4 | |
| SCHEMBL185657 | 0.70 | CCR4 (0.41) | CCR4 | |
| SCHEMBL185711 | 0.70 | CCR4 (0.70) | CCR4 | |
| SCHEMBL186961 | 0.70 | CCR4 (0.44) | CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401270-A1 | PYRAZOLE DERIVATIVES USED AS CCR4 RECEPTOR ANTAGONISTS | Glaxo Group Limited (GB) | 2012-01-04 | — | — | EP | disclosed |