Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 13/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.36 |
| ▸ | CCR4 | P51679 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18648360 | 0.89 | TLR7 (0.53) | TLR7TLR8KCNH2 | |
| SCHEMBL18644344 | 0.89 | TLR7 (0.53) | TLR7TLR8KCNH2 | |
| SCHEMBL18644353 | 0.81 | TLR7 (0.37) | TLR7TLR8KCNH2 | |
| SCHEMBL23472393 | 0.79 | TLR7 (0.40) | TLR7TLR8KCNH2 | |
| SCHEMBL20413303 | 0.79 | TLR7 (0.37) | TLR7TLR8KCNH2 | |
| SCHEMBL23472404 | 0.76 | TLR7 (0.51) | TLR7TLR8KCNH2 | |
| SCHEMBL20413266 | 0.74 | TRPM8 (0.41) | TLR7TLR8 | |
| SCHEMBL20386702 | 0.74 | TLR7 (0.46) | TLR7TLR8KCNH2 | |
| SCHEMBL19274277 | 0.73 | TLR7 (0.48) | TLR7TLR8KCNH2 | |
| SCHEMBL13195144 | 0.73 | TLR7 (0.63) | TLR7TLR8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9598378-B2 | 2-aminopyrimidine derivatives for the treatment of viral infections | JANSSEN SCIENCES IRELAND UC (IE) | 2017-03-21 | — | — | US | disclosed |