Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 6/20 | 0.36 |
| ▸ | RORB | Q92753 | 3/20 | 0.36 |
| ▸ | RORA | P35398 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21710567 | 0.88 | GPR119 (0.37) | USP2SMN1; SMN2GPR119KDM4EMAPT | |
| SCHEMBL18590704 | 0.87 | RORC (0.38) | USP2SMN1; SMN2GPR119SCD5RORC | |
| SCHEMBL18646542 | 0.87 | USP2 (0.35) | USP2SMN1; SMN2GPR119KDM4EMAPT | |
| SCHEMBL21710542 | 0.87 | RORC (0.38) | USP2SMN1; SMN2GPR119SCD5RORC | |
| SCHEMBL21710554 | 0.81 | USP2 (0.40) | USP2SMN1; SMN2GPR119AVPR1ASCD5 | |
| SCHEMBL18590703 | 0.81 | USP2 (0.40) | USP2SMN1; SMN2GPR119AVPR1ASCD5 | |
| SCHEMBL18579748 | 0.81 | USP2 (0.40) | USP2SMN1; SMN2GPR119AVPR1ASCD5 | |
| SCHEMBL31283114 | 0.76 | USP2 (0.45) | USP2SMN1; SMN2GPR119KDM4EMAPT | |
| SCHEMBL18647655 | 0.75 | RORC (0.53) | THRBRORCRORBRORA | |
| SCHEMBL21710433 | 0.75 | RORC (0.57) | GPR119RORCRORBRORA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3347360-B1 | COMPOUNDS USEFUL FOR INHIBITING ROR-GAMMA-T | LILLY CO ELI (US) | 2019-10-23 | — | — | EP | disclosed |
| WO-2017044410-A1 | COMPOUNDS USEFUL FOR INHIBITING ROR-GAMMA-T | ELI LILLY AND COMPANY (US) | 2017-03-16 | — | — | WO | disclosed |