Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9192605 | 0.75 | KMT2A (0.47) | SLC6A2SLC6A3HTR2ASLC6A4HRH1 | |
| SCHEMBL13573320 | 0.71 | ALDH1A1 (0.54) | ALDH1A1KMT2AHSP90AB1GAAPOLB | |
| SCHEMBL13656002 | 0.71 | PTGER4 (0.45) | ALDH1A1SLC6A2SLC6A3HTR2ASLC6A4 | |
| Hydrochloric Acid SCHEMBL4282177 | 0.70 | ALDH1A1 (0.53) | ALDH1A1KMT2AHSP90AB1GAAPOLB | |
| SCHEMBL3985532 | 0.69 | HSP90AB1 (0.43) | ALDH1A1SLC6A2SLC6A3HTR2ASLC6A4 | |
| SCHEMBL13230149 | 0.68 | ALDH1A1 (0.41) | ALDH1A1KMT2ATAAR1POLB | |
| SCHEMBL9185748 | 0.68 | KMT2A (0.43) | SLC6A2SLC6A3HTR2ASLC6A4HRH1 | |
| SCHEMBL15384259 | 0.68 | ALDH1A1 (0.50) | ALDH1A1KMT2AHSP90AB1GAAPOLB | |
| SCHEMBL10907646 | 0.67 | CD44 (0.41) | ALDH1A1SLC6A2SLC6A3HTR2ASLC6A4 | |
| SCHEMBL22271633 | 0.66 | FHIT (0.35) | ALDH1A1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3347356-B1 | TRICYCLIC FUSED PYRIDIN-2-ONE DERIVATIVES AND THEIR USE AS BRD4 INHIBITORS | JUBILANT BIOSYS LTD (IN) | 2021-03-24 | — | — | EP | disclosed |
| WO-2017042834-A1 | TRICYCLIC FUSED PYRIDIN-2-ONE DERIVATIVES AND THEIR USE AS BRD4 INHIBITORS | JUBILANT BIOSYS LIMITED (IN) | 2017-03-16 | — | — | WO | disclosed |