Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 4/20 | 0.32 |
| ▸ | FAAH | O00519 | 4/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | RORB | Q92753 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2809443 | 0.90 | BDKRB1 (0.41) | BDKRB1RORCPDE10ANPC1TRPA1 | |
| SCHEMBL14856577 | 0.86 | FAAH (0.34) | BDKRB1FAAHTRPV1TRPA1 | |
| SCHEMBL14856725 | 0.83 | FAAH (0.45) | FAAHTRPV1 | |
| SCHEMBL14856769 | 0.82 | CNR2 (0.36) | BDKRB1FAAHTRPV1RORCNPC1 | |
| SCHEMBL14856710 | 0.82 | FAAH (0.35) | FAAHTRPV1RORCTRPA1RORB | |
| SCHEMBL14856774 | 0.82 | FAAH (0.34) | BDKRB1FAAHTRPV1TRPA1 | |
| SCHEMBL14856682 | 0.82 | FAAH (0.36) | BDKRB1FAAHTRPV1 | |
| SCHEMBL185551 | 0.82 | CNR2 (0.33) | FAAHTRPV1 | |
| SCHEMBL185940 | 0.82 | CNR2 (0.34) | FAAHTRPV1 | |
| SCHEMBL2782059 | 0.82 | BDKRB1 (0.39) | BDKRB1FAAHTRPV1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |