Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | GAA | P10253 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12548427 | 0.79 | HSD17B10 (0.54) | HSD17B10GABRA5GABRB2ALDH1A1GAA | |
| SCHEMBL1706522 | 0.78 | HSD17B10 (0.58) | HSD17B10GABRA5GABRB2ALDH1A1GAA | |
| SCHEMBL163023 | 0.77 | NPC1 (0.37) | HSD17B10ALDH1A1GAANPC1RAB9A | |
| SCHEMBL30567660 | 0.77 | HDAC3 (0.46) | HSD17B10ALDH1A1GAAMAPTNPC1 | |
| SCHEMBL163024 | 0.77 | NPC1 (0.37) | HSD17B10ALDH1A1GAANPC1RAB9A | |
| SCHEMBL2422284 | 0.76 | PRKCZ (0.38) | HSD17B10ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL11130654 | 0.75 | HSD17B10 (0.62) | HSD17B10GABRA5GABRB2ALDH1A1GAA | |
| SCHEMBL10067956 | 0.74 | GAA (0.55) | HSD17B10GABRA5GABRB2ALDH1A1GAA | |
| SCHEMBL18971953 | 0.74 | HSD17B10 (0.53) | HSD17B10GABRA5GABRB2ALDH1A1GAA | |
| SCHEMBL5875662 | 0.74 | SMN1; SMN2 (0.45) | HSD17B10GABRA5GABRB2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9597318-B2 | 2-oxothiazole compounds and method of using same for chronic inflammatory disorders | AVEXXIN AS (NO) | 2017-03-21 | — | — | US | disclosed |