Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9199700 | 0.73 | POLB (0.45) | POLBKMT2AGAAMEN1HSD17B10 | |
| SCHEMBL352276 | 0.72 | GAA (0.53) | POLBKMT2AGAAMEN1HSD17B10 | |
| SCHEMBL3867543 | 0.71 | POLB (0.41) | POLBKMT2AGAAMEN1HSD17B10 | |
| SCHEMBL9446208 | 0.71 | RAB9A (0.42) | POLBKMT2AGAAMEN1HSD17B10 | |
| Hydrochloric Acid SCHEMBL5009791 | 0.71 | GAA (0.51) | POLBKMT2AGAAMEN1HSD17B10 | |
| SCHEMBL3559531 | 0.71 | POLB (0.50) | POLBKMT2AGAAMEN1HSD17B10 | |
| SCHEMBL1667303 | 0.69 | POLB (0.40) | POLBKMT2AGAAMEN1CYP2C9 | |
| SCHEMBL19240419 | 0.67 | POLB (0.46) | POLBKMT2AGAAMEN1HSD17B10 | |
| SCHEMBL6612159 | 0.67 | POLB (0.46) | POLBKMT2AGAAMEN1HSD17B10 | |
| SCHEMBL17031862 | 0.67 | POLB (0.46) | POLBKMT2AGAAMEN1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017046117-A1 | SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE | ABBVIE INC. (US) | 2017-03-23 | — | — | WO | disclosed |