Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | SMG1 | Q96Q15 | 9/20 | 0.41 |
| ▸ | MTOR | P42345 | 5/20 | 0.41 |
| ▸ | CDK1 | P06493 | 4/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NR2C2 | P49116 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18627898 | 0.87 | SYK (0.56) | SYKSMG1MTORCDK1CDK2 | |
| SCHEMBL18652476 | 0.86 | SYK (0.45) | SYKSMG1MTORCDK1CDK2 | |
| SCHEMBL18627934 | 0.82 | SYK (0.56) | SYKSMG1MTORCDK1CDK2 | |
| SCHEMBL18627907 | 0.81 | SYK (0.54) | SYKSMG1MTORCDK1CDK2 | |
| SCHEMBL18627955 | 0.77 | SYK (0.45) | SYKSMG1MTORCDK1CDK2 | |
| SCHEMBL18627930 | 0.76 | SYK (0.43) | SYKSMG1MTORCDK1CDK2 | |
| SCHEMBL17113289 | 0.76 | SYK (0.67) | SYKSMG1MTORCDK1CDK2 | |
| SCHEMBL18627953 | 0.75 | SYK (0.61) | SYKSMG1MTORCDK1CDK2 | |
| SCHEMBL18627929 | 0.75 | SYK (0.57) | SYKSMG1MTORCDK1CDK2 | |
| SCHEMBL18652274 | 0.74 | SYK (0.58) | SYKSMG1CDK1CDK2CAMK2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017046302-A1 | NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK | AB SCIENCE (FR) | 2017-03-23 | — | — | WO | disclosed |