Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | SMG1 | Q96Q15 | 4/20 | 0.37 |
| ▸ | CDK1 | P06493 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 7/20 | 0.37 |
| ▸ | JAK3 | P52333 | 5/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 3/20 | 0.36 |
| ▸ | ABL2 | P42684 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18627938 | 0.87 | SYK (0.57) | SYKABL1BCRBRD4SMG1 | |
| SCHEMBL18652487 | 0.86 | SYK (0.45) | SYKSMG1CDK1CDK2MTOR | |
| SCHEMBL17113590 | 0.81 | SYK (0.69) | SYKABL1BCRBRD4SMG1 | |
| SCHEMBL18627957 | 0.77 | SYK (0.45) | SYKABL1BCRBRD4SMG1 | |
| SCHEMBL18627953 | 0.76 | SYK (0.61) | SYKABL1BCRSMG1CDK1 | |
| SCHEMBL18627929 | 0.75 | SYK (0.57) | SYKABL1BCRSMG1CDK1 | |
| SCHEMBL18627919 | 0.75 | SYK (0.43) | SYKABL1BCRBRD4SMG1 | |
| SCHEMBL18652274 | 0.75 | SYK (0.58) | SYKABL1BCRSMG1CDK1 | |
| SCHEMBL18627934 | 0.75 | SYK (0.56) | SYKABL1BCRSMG1CDK1 | |
| SCHEMBL18640375 | 0.74 | SYK (0.41) | SYKABL1BCRBRD4SMG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017046302-A1 | NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK | AB SCIENCE (FR) | 2017-03-23 | — | — | WO | disclosed |