Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | NNMT | P40261 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9329411 | 0.82 | HCAR2 (0.37) | KDM4EALDH1A1ATMHCAR2 | |
| SCHEMBL9659243 | 0.76 | HCAR2 (0.38) | KDM4EALDH1A1GRM5ATMHCAR2 | |
| SCHEMBL15360302 | 0.75 | BRAF (0.37) | BRAFFYN | |
| Hydrochloric Acid SCHEMBL28433351 | 0.73 | BRAF (0.36) | BRAFFYN | |
| SCHEMBL186537 | 0.72 | CTSA (0.46) | HCAR3KDM4EALDH1A1CTSAGRM5 | |
| SCHEMBL2924939 | 0.72 | CDK2 (0.39) | KDM4EALDH1A1CTSAGRM5HCAR2 | |
| SCHEMBL186349 | 0.72 | CDK2 (0.39) | KDM4EALDH1A1NNMTHCAR2 | |
| SCHEMBL4265537 | 0.70 | HCAR2 (0.39) | KDM4EALDH1A1ATMHCAR2 | |
| SCHEMBL22792226 | 0.68 | LOX (0.41) | FYN | |
| SCHEMBL29031595 | 0.68 | ALDH1A1 (0.42) | KDM4EALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |