Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.38 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18590994 | 0.86 | RXFP1 (0.46) | PDE10APIM1HTTSMN1; SMN2AAK1 | |
| SCHEMBL23408640 | 0.84 | PIM1 (0.40) | PDE10APIM1IRAK4SMN1; SMN2AAK1 | |
| SCHEMBL14882280 | 0.83 | PIM1 (0.42) | PDE10APIM1IRAK4HTTSMN1; SMN2 | |
| SCHEMBL14881665 | 0.83 | PIM1 (0.42) | PDE10APIM1IRAK4HTTSMN1; SMN2 | |
| SCHEMBL23408576 | 0.80 | PIM1 (0.40) | PIM1IRAK4AAK1MAP3K7DYRK3 | |
| SCHEMBL12411727 | 0.79 | SMN1; SMN2 (0.55) | PDE10APIM1HTTSMN1; SMN2DYRK3 | |
| SCHEMBL15258013 | 0.79 | HTT (0.59) | PDE10APIM1HTTSMN1; SMN2DYRK3 | |
| SCHEMBL14881458 | 0.79 | IRAK4 (0.47) | PIM1IRAK4AAK1DYRK3CCNT1 | |
| SCHEMBL14881490 | 0.79 | IRAK4 (0.47) | PIM1IRAK4AAK1DYRK3CCNT1 | |
| SCHEMBL21765966 | 0.78 | IRAK4 (0.46) | PIM1IRAK4AAK1DYRK3CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3840832-B1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LTD (GB) | 2023-10-11 | — | — | EP | disclosed |
| WO-2022234287-A1 | IMIDAZOPYRIDAZINE DERIVATIVES USEFUL AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2022-11-10 | — | — | WO | disclosed |
| WO-2021148805-A1 | TOPICAL PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZO[1,2-B]PYRIDAZINE COMPOUNDS | BENEVOLENTAI BIO LIMITED (GB) | 2021-07-29 | — | — | WO | disclosed |
| WO-2021098745-A1 | PREPARATION AND APPLICATION OF A CLASS OF PROTEIN RECEPTOR KINASE INHIBITORS | 上海轶诺药业有限公司 | 2021-05-27 | — | — | WO | disclosed |
| WO-2020039209-A1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2020-02-27 | — | — | WO | disclosed |