Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186187 | 0.93 | TRPV1 (0.36) | FAAHTRPV1MEN1KMT2AHPGD | |
| SCHEMBL14856700 | 0.93 | FAAH (0.38) | FAAHTRPV1MEN1KMT2ADHODH | |
| SCHEMBL185516 | 0.92 | OPRL1 (0.36) | FAAHTRPV1DHODHNTRK1OPRL1 | |
| SCHEMBL186076 | 0.91 | CNR2 (0.37) | FAAHTRPV1DHODHCYP1A2CYP2C19 | |
| SCHEMBL2807541 | 0.89 | DHODH (0.35) | MEN1KMT2ADHODHMAPK9MAPK10 | |
| SCHEMBL185703 | 0.89 | FAAH (0.37) | FAAHTRPV1HPGDMAPK9MAPK10 | |
| SCHEMBL185388 | 0.86 | OPRL1 (0.36) | FAAHTRPV1NTRK1OPRL1 | |
| SCHEMBL185850 | 0.86 | FAAH (0.38) | FAAHTRPV1HPGDMAPK9MAPK10 | |
| SCHEMBL186281 | 0.86 | OPRL1 (0.36) | FAAHTRPV1DHODHNTRK1OPRL1 | |
| SCHEMBL14856574 | 0.85 | CNR2 (0.35) | FAAHTRPV1CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |