Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | FAAH | O00519 | 2/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.30 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185516 | 0.94 | OPRL1 (0.36) | OPRL1CNR2FAAHTRPV1DHODH | |
| SCHEMBL14856439 | 0.93 | FAAH (0.33) | OPRL1CNR2FAAHTRPV1DHODH | |
| SCHEMBL186543 | 0.92 | OPRL1 (0.34) | OPRL1CNR2FAAHTRPV1P2RX7 | |
| SCHEMBL2805695 | 0.91 | OPRL1 (0.37) | OPRL1CNR2DHODH | |
| SCHEMBL185881 | 0.88 | OPRL1 (0.37) | OPRL1CNR2FAAHTRPV1P2RX7 | |
| SCHEMBL185388 | 0.88 | OPRL1 (0.36) | OPRL1CNR2FAAHTRPV1NTRK1 | |
| SCHEMBL186992 | 0.87 | CNR2 (0.33) | CNR2FAAHTRPV1P2RX7 | |
| SCHEMBL186076 | 0.87 | CNR2 (0.37) | CNR2FAAHTRPV1DHODHP2RX7 | |
| SCHEMBL14856590 | 0.86 | FAAH (0.35) | OPRL1CNR2FAAHTRPV1DHODH | |
| SCHEMBL186188 | 0.86 | CNR2 (0.35) | CNR2FAAHTRPV1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |