Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 9/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.37 |
| ▸ | FYN | P06241 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654753 | 0.87 | FYN (0.42) | TGFBR1NTRK1FYN | |
| SCHEMBL18654405 | 0.85 | TGFBR1 (0.39) | TGFBR1CHRM4NTRK1FYNF2 | |
| SCHEMBL18654415 | 0.84 | TP53 (0.36) | CHRM4NTRK1ATR | |
| SCHEMBL14897192 | 0.81 | TGFBR1 (0.46) | TGFBR1CHRM4NTRK1ATR | |
| SCHEMBL14897111 | 0.80 | TGFBR1 (0.49) | TGFBR1CHRM4NTRK1FYNF2 | |
| SCHEMBL14897613 | 0.80 | TGFBR1 (0.47) | TGFBR1CHRM4NTRK1FYNF2 | |
| SCHEMBL16193096 | 0.80 | TGFBR1 (0.49) | TGFBR1CHRM4NTRK1FYNF2 | |
| SCHEMBL18654566 | 0.80 | TGFBR1 (0.38) | TGFBR1CHRM4NTRK1FYNF2 | |
| SCHEMBL14896826 | 0.80 | TGFBR1 (0.56) | TGFBR1 | |
| SCHEMBL14897363 | 0.80 | NPC1 (0.45) | TGFBR1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |