Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 10/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654743 | 0.90 | MAPT (0.36) | TP53NTRK1HDAC1CSNK1DCSNK1E | |
| SCHEMBL18655239 | 0.88 | CSNK1D (0.38) | CSNK1DCSNK1E | |
| SCHEMBL18654323 | 0.88 | NTRK1 (0.35) | TP53NTRK1HDAC1CSNK1DCSNK1E | |
| SCHEMBL18654741 | 0.87 | MAPT (0.35) | TP53NTRK1HDAC1CHRM4ATR | |
| SCHEMBL18654742 | 0.87 | RIPK1 (0.40) | NTRK1CSNK1DCSNK1E | |
| SCHEMBL18654758 | 0.84 | TGFBR1 (0.43) | NTRK1CHRM4ATR | |
| SCHEMBL14896760 | 0.81 | TYK2 (0.43) | NTRK1ATR | |
| SCHEMBL18654627 | 0.81 | KIT (0.35) | NTRK1HDAC1CSNK1DCSNK1ECHRM4 | |
| SCHEMBL14897468 | 0.80 | NPC1 (0.36) | TP53NTRK1HDAC1CSNK1DCSNK1E | |
| SCHEMBL14896789 | 0.80 | GRM5 (0.40) | TP53NTRK1CSNK1DCSNK1EATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |