Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 7/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.32 |
| ▸ | FYN | P06241 | 4/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18655245 | 0.83 | TGFBR1 (0.36) | NTRK1CHRM4TGFBR1TGFBR2 | |
| SCHEMBL18654566 | 0.81 | TGFBR1 (0.38) | NTRK1CHRM4TGFBR1FYN | |
| SCHEMBL18654526 | 0.79 | FYN (0.38) | TGFBR1FYNTGFBR2 | |
| SCHEMBL18655069 | 0.79 | NTRK1 (0.34) | NTRK1CHRM4TGFBR1FYNTGFBR2 | |
| SCHEMBL16265218 | 0.78 | MKNK1 (0.35) | NTRK1CHRM4TGFBR1TGFBR2MKNK1 | |
| SCHEMBL14897141 | 0.78 | ATR (0.36) | TGFBR1FYNTGFBR2 | |
| SCHEMBL18655017 | 0.78 | TGFBR1 (0.35) | NTRK1CHRM4TGFBR1TGFBR2 | |
| SCHEMBL14882163 | 0.77 | CSF1R (0.40) | NTRK1CHRM4TGFBR1MKNK1 | |
| SCHEMBL14897018 | 0.77 | CSF1R (0.40) | NTRK1CHRM4TGFBR1MKNK1 | |
| SCHEMBL14881767 | 0.77 | CSF1R (0.40) | NTRK1CHRM4TGFBR1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |