Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 10/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14896830 | 0.80 | TGFBR1 (0.40) | FYNTGFBR1 | |
| SCHEMBL14897290 | 0.80 | TGFBR1 (0.40) | FYNTGFBR1 | |
| SCHEMBL18655184 | 0.79 | NTRK1 (0.33) | FYNTGFBR1TGFBR2 | |
| SCHEMBL14896883 | 0.79 | TGFBR1 (0.44) | FYNTGFBR1CSF1R | |
| SCHEMBL14897519 | 0.79 | CHRNB2 (0.42) | FYNTGFBR1 | |
| SCHEMBL14897103 | 0.79 | TGFBR1 (0.44) | FYNTGFBR1CSF1R | |
| SCHEMBL14897447 | 0.79 | TGFBR1 (0.42) | FYNTGFBR1TGFBR2CSF1R | |
| SCHEMBL14896831 | 0.79 | TGFBR1 (0.50) | FYNTGFBR1CSF1R | |
| SCHEMBL14897464 | 0.79 | FYN (0.41) | FYNTGFBR1 | |
| SCHEMBL14896879 | 0.79 | TGFBR1 (0.50) | FYNTGFBR1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |